I-Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Factory High Purity

Incazelo emfushane:

Igama leKhemikhali: Tacrolimus

Amazwi afanayo: FK-506;I-Fujimycin

I-CAS: 104987-11-3

Ukubukeka: Impushana Emhlophe Emhlophe noma Ephuzi Ngokuphaphathekile, Ayinaphunga, Ukunambitheka Okumnandi Okukhethekile

I-Assay: ≥72.0% (HPLC, ngesisekelo esomisiwe)

I-API, Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

E-mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama leKhemikhali: Tacrolimus
Amazwi afanayo: FK-506;I-Fujimycin
I-CAS: 104987-11-3
I-API, Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

Chemical Properties:

Igama Lekhemikhali	I-Tacrolimus
Omqondofana	I-FK-506;I-Fujimycin
Inombolo ye-CAS	104987-11-3
Inombolo yeCAT	I-RF-API46
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C44H69NO12
Isisindo samangqamuzana	804.02
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	I-Off-White noma I-Pale Yellow Fine Powder, Ayinaphunga, Ukunambitheka Okumnandi Okukhethekile
Ukuhlonza	Kufanele kube Ukusabela Okuhle
Ukucaca	Landela Izinga
pH	5.0~6.0
I-Chloride	≤0.014%
I-Sulfate	≤0.029%
Izinsimbi Ezisindayo (Pb)	≤10ppm
I-Arsenic	≤0.0002%
Umswakama (KF)	≤8.0%
Izinsalela ekushiseni	18.0%~22.0%
Isivivinyo	≥72.0% (HPLC, ngesisekelo esomisiwe)
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-API

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Tacrolimus (futhi i-FK-506 noma i-Fujimycin) iyisidakamizwa esivimbela ukuzivikela komzimba ekusetshenzisweni kwayo okuyinhloko ngemva kokufakelwa kwesitho somzimba ukuze kuncishiswe umsebenzi wamasosha omzimba esiguli kanjalo nobungozi bokwenqatshwa kwesitho.Ibuye isetshenziswe ekulungiseleleni ama-topical ekwelapheni i-atopic dermatitis enzima, i-refractory uveitis eqinile ngemva kokufakelwa komnkantsha wethambo, kanye nesimo sesikhumba se-vitiligo.I-Tacrolimus yaqala ukukhishwa kumhluzi wokuvubela we-Streptomyces tssukuba, igciwane lenhlabathi elitholakala eTsukuba, eJapane.Igama elithi tacrolimus lisuselwa ngokuthatha elithi 't' le-Tsukuba, igama lentaba lapho isampula yomhlabathi yakhishwa khona, 'acrol' ye-macrolide kanye ne-'imus' ye-immunosuppressant.Nakuba ngokwesakhiwo ingahlobene ne-cyclosporin, i-tacrolimus ibonisa i-spectrum efanayo yemiphumela ye-immunosuppressive kule ejenti ezingeni lamangqamuzana namangqamuzana.Ucwaningo lokuqala lubonise ukuthi i-tacrolimus yayiyi-immunosuppressant enamandla, ibonisa amandla e-in vitro cishe izikhathi eziyi-100 kune-cyclosporin ekuvimbeleni ukusebenza kwe-T cell.Ucwaningo olwalandela lwe-vivo lubonise i-tacrolimus ukuthi iyasebenza kokubili ekucindezeleni isifo esizenzakalelayo nesilingo sokuzivikela komzimba, nasekuvimbeleni ukwenqatshwa kwe-allograft kanye ne-xenograft kumamodeli ezilwane okufakelwa kwezitho zomzimba.Ekuqaleni, i-tacrolimus yayisetshenziselwa i-systemic immunosuppression yeziguli ezake zafakwa i-allograft ukuze ziyeke ukwenqaba ukuxhunyelelwa kwazo okusha.Nokho, ngokushesha, ngokuzuza kokuzola kwesayensi, kwaqashelwa ukuthi i-tacrolimus ingaveza imiphumela emihle ekuphazamisekeni kwesikhumba kwezinye zeziguli ezazifakwe ukufakelwa.Ngakho ukutholakala kwe-tacrolimus kuye kwaholela ekuqondeni okwengeziwe kwe-pathology yesikhumba, isibonelo se-atopic dermatitis.Kamuva, ezinye izicelo ze-topical ze-tacrolimus zabikwa futhi ukusetshenziswa kwalesi ejenti ku-dermatology kukhula kancane kancane.