I-Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Factory High Purity
Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama leKhemikhali: Tacrolimus
Amazwi afanayo: FK-506;I-Fujimycin
I-CAS: 104987-11-3
I-API, Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo
Igama Lekhemikhali | I-Tacrolimus |
Omqondofana | I-FK-506;I-Fujimycin |
Inombolo ye-CAS | 104987-11-3 |
Inombolo yeCAT | I-RF-API46 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C44H69NO12 |
Isisindo samangqamuzana | 804.02 |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Off-White noma I-Pale Yellow Fine Powder, Ayinaphunga, Ukunambitheka Okumnandi Okukhethekile |
Ukuhlonza | Kufanele kube Ukusabela Okuhle |
Ukucaca | Landela Izinga |
pH | 5.0~6.0 |
I-Chloride | ≤0.014% |
I-Sulfate | ≤0.029% |
Izinsimbi Ezisindayo (Pb) | ≤10ppm |
I-Arsenic | ≤0.0002% |
Umswakama (KF) | ≤8.0% |
Izinsalela ekushiseni | 18.0%~22.0% |
Isivivinyo | ≥72.0% (HPLC, ngesisekelo esomisiwe) |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-API |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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I-Tacrolimus (futhi i-FK-506 noma i-Fujimycin) iyisidakamizwa esivimbela ukuzivikela komzimba ekusetshenzisweni kwayo okuyinhloko ngemva kokufakelwa kwesitho somzimba ukuze kuncishiswe umsebenzi wamasosha omzimba esiguli kanjalo nobungozi bokwenqatshwa kwesitho.Ibuye isetshenziswe ekulungiseleleni ama-topical ekwelapheni i-atopic dermatitis enzima, i-refractory uveitis eqinile ngemva kokufakelwa komnkantsha wethambo, kanye nesimo sesikhumba se-vitiligo.I-Tacrolimus yaqala ukukhishwa kumhluzi wokuvubela we-Streptomyces tssukuba, igciwane lenhlabathi elitholakala eTsukuba, eJapane.Igama elithi tacrolimus lisuselwa ngokuthatha elithi 't' le-Tsukuba, igama lentaba lapho isampula yomhlabathi yakhishwa khona, 'acrol' ye-macrolide kanye ne-'imus' ye-immunosuppressant.Nakuba ngokwesakhiwo ingahlobene ne-cyclosporin, i-tacrolimus ibonisa i-spectrum efanayo yemiphumela ye-immunosuppressive kule ejenti ezingeni lamangqamuzana namangqamuzana.Ucwaningo lokuqala lubonise ukuthi i-tacrolimus yayiyi-immunosuppressant enamandla, ibonisa amandla e-in vitro cishe izikhathi eziyi-100 kune-cyclosporin ekuvimbeleni ukusebenza kwe-T cell.Ucwaningo olwalandela lwe-vivo lubonise i-tacrolimus ukuthi iyasebenza kokubili ekucindezeleni isifo esizenzakalelayo nesilingo sokuzivikela komzimba, nasekuvimbeleni ukwenqatshwa kwe-allograft kanye ne-xenograft kumamodeli ezilwane okufakelwa kwezitho zomzimba.Ekuqaleni, i-tacrolimus yayisetshenziselwa i-systemic immunosuppression yeziguli ezake zafakwa i-allograft ukuze ziyeke ukwenqaba ukuxhunyelelwa kwazo okusha.Nokho, ngokushesha, ngokuzuza kokuzola kwesayensi, kwaqashelwa ukuthi i-tacrolimus ingaveza imiphumela emihle ekuphazamisekeni kwesikhumba kwezinye zeziguli ezazifakwe ukufakelwa.Ngakho ukutholakala kwe-tacrolimus kuye kwaholela ekuqondeni okwengeziwe kwe-pathology yesikhumba, isibonelo se-atopic dermatitis.Kamuva, ezinye izicelo ze-topical ze-tacrolimus zabikwa futhi ukusetshenziswa kwalesi ejenti ku-dermatology kukhula kancane kancane.
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