I-Temozolomide (TMZ) CAS 85622-93-1 Assay 99.0%~101.0% API Factory High Purity
Nikeza i-Temozolomide kanye Nezixhumanisi Ezihlobene:
I-Temozolomide CAS: 85622-93-1
4(5)-Amino-5(4)-Imidazolecarboxamide CAS: 360-97-4
5(4)-Amino-4(5)-Imidazolecarboxamide Hydrochloride CAS: 72-40-2
| Igama Lekhemikhali | I-Temozolomide |
| Omqondofana | 3,4-Dihydro-3-Methyl-4-Oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-Carboxamide |
| Inombolo ye-CAS | 85622-93-1 |
| Inombolo yeCAT | I-RF-API29 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C6H6N6O2 |
| Isisindo samangqamuzana | 194.15 |
| I-Melting Point | 212 ℃ dec. |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Epinki Emhlophe ukuya Ekhanyayo |
| Ukuhlonza | Nge-IR, HPLC |
| Izincibilikisi Ezisele | I-Dimethyl Sulphoxide ≤0.50% |
| Izinto Ezihlobene | |
| Ukungcola kwe-AIC | ≤0.10% |
| Ukungcola Okukodwa | ≤0.10% |
| Phumula Ukungcola Okungaziwa | ≤0.30% |
| Ukungcola Okuphelele | ≤0.30% |
| Izinsimbi Ezisindayo | ≤10ppm |
| Ukulahlekelwa Ekumisweni | ≤0.50% |
| Izinsalela ekushiseni | ≤0.10% |
| Isivivinyo | 99.0%~101.0% (HPLC ngokomisiwe) |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Active Pharmaceutical Ingredient (API) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomphakeli we-Temozolomide (CAS: 85622-93-1) enekhwalithi ephezulu.I-Temozolomide (TMZ) i-ejenti yomlomo ye-alkylating esetshenziselwa ukwelapha i-Glioblastoma Multiforme (GBM) kanye ne-Astrocytomas, i-Metastatic Melanoma.
I-Temozolomide iyisidakamizwa sokuqala esithathwa ngomlomo imidazole kanye ne-tetrazine-class anticancer esetshenziswa esizukulwaneni sesibili se-alkylating agent enomsebenzi we-antitumor ngaphandle kokusebenza kwesibindi sokusebenza kwe-metabolic ngemva kokuphathwa ngomlomo.Ibonakala ngokungena kalula ngomgoqo wegazi nobuchopho, ukubekezelelana okuhle nokungagxili kwezinye izidakamizwa ubuthi, futhi ibe nomthelela wokusebenzisana ne-radiotherapy elungele ukwelapha ukuvela kabusha kwe-glioma ebulalayo ngemva kokwelashwa okuvamile okufana ne-glioblastoma multiforme tumors noma i-astrocytoma ewohlokayo.Umuthi womugqa wokuqala wokwelapha i-melanoma ye-metastatic.
I-Temozolomide yayiqale ukuhlanganiswa yiCancer Research UK Group, yase idluliselwa eNkampanini ye-Schering-Plough (United States) ukuze ithuthukiswe.Inesakhiwo samakhemikhali esinoveli futhi ingeyokuphuma kwe-imidazole emine.Ngo-1999, igunyazwe ukuthi lifakwe emakethe e-EU nase-US lapho inkomba evunyelwe e-United States ihloselwe ikakhulukazi ukwelashwa komugqa wesibili we-glioblastoma multiforme kanye ne-degenerative star gliomas kanye nezinkomba ezigunyaziwe ze-EU ezokwelapha ezikhulayo noma ezibuyisela kabusha i-glioblastoma multiforme. osekuvele kungaphansi kokwelashwa okujwayelekile.Ukusebenza kwe-temozolomide ekwelapheni i-glioblastoma multiforme sekuthole ukuqashelwa okwengeziwe eYurophu.
