I-Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Factory Anti-HIV High Quality

Incazelo emfushane:

Igama: I-Tenofovir Alafenamide Hemifumarate (TAF)

I-CAS: 1392275-56-7

Amakristalu Amhlophe kuya Kucishe Amhlophe noma I-Crystalline Powder

Isilinganiso: 98.0%~102.0%

Umuthi we-Tenofovir, osetshenziswa ekwelapheni okuxubile ekwelapheni I-HIV-1 Infection

Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

Inquiry: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Tenofovir Commercial Related Intermediate:
I-Tenofovir CAS: 147127-20-6
I-Tenofovir Disoproxil Fumarate CAS 202138-50-9
I-Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
I-Chloromethyl Isopropyl Carbonate CAS 35180-01-9
I-Diethyl (p-Toluenesulfonyloxymethyl)phosphonate CAS 31618-90-3
(R)-(+)-Propylene Carbonate CAS 16606-55-6
(R)-9-(2-Hydroxypropyl)adenine CAS 14047-28-0
I-Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
I-Adenine CAS 73-24-5

Chemical Properties:

Igama Lekhemikhali	I-Tenofovir Alafenamide Hemifumarate
Omqondofana	I-TAF;I-GS-7340 Hemifumarate
Inombolo ye-CAS	1392275-56-7
Inombolo yeCAT	I-RF-API91
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu
I-Molecular Formula	I-C25H33N6O9P
Isisindo samangqamuzana	592.55
Izinga Lokushisa Lesitoreji	Kuvalwe kokuthi Omile, Izinga lokushisa Legumbi
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Amakristalu Amhlophe kuya Kucishe Amhlophe noma I-Crystalline Powder
Ukuncibilika	I-Soluble ku-Dimethylformamide, ne-Methanol;Incibilika Kancane Emanzini naku-THF;Incibilika Kancane ku-Acetonitrile futhi Ayincibiliki ku-Dichloromethane ne-Toluene
Ukuhlonza A	I-spectra yokumuncwa kwe-IR kufanele ihambisane nereferensi
Ukuhlonza B	Isikhathi sokugcinwa sesiqongo esikhulu sesixazululo sesampula ku-chromatogram yokunquma okuqukethwe sihambisana naleso sesixazululo sereferensi.
Ukuhlonza C	Isikhathi sokugcinwa kwe-Fumaric Acid senani eliphakeme le-chromatogram yokunquma okuqukethwe sivumelana nenani eliphakeme lesithenjwa
Okuqukethwe kwamanzi (nge-KF)	≤1.0%
Ukucaca Kwesixazululo	Ngokuyisisekelo azikho izinhlayiya ezibonakalayo ku-2% (w/v) yokucaciswa kweMethanol Solution
I-Residual Solvent
I-acetonitrile	≤410ppm
I-Ethanol	≤5000ppm
I-Dichloromethane	≤600ppm
I-Toluene	≤890ppm
Izinsalela ekushiseni	≤0.10%
Izinsimbi Ezisindayo	≤20ppm
Izinto Ezihlobene
I-PMPA	≤1.0%
I-PMPA Anhydride	≤0.75%
I-Phenyl PMPA eyodwa	≤1.0%
Noma Ikuphi Ukungcola Okungashiwongo	≤0.15%
Ukungcola Okuphelele	≤2.0%
Isomer	≤1.0%
Okuqukethwe kwe-Fumaric Acid	9.0%~13.0% (kwisisekelo esingenamanzi)
Imikhawulo yeMicrobial
Isamba se-Aerobic Microbial Count	≤1000CFU/g
Isamba Semvubelo Nesikhunta Sibala	≤100CFU/g
Escherichia Coli	Akekho
Isivivinyo	98.0%~102.0% (ngesisekelo se-anhydrous ne-solvent-free)
Izinga Lokuhlola	I-Enterprise Standard

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, iyi-nucleotide reverse transcriptase inhibitor (NRTIs) kanye ne-prodrug yenoveli ye-Tenofovir (TFV).Ngokuvimbela i-reverse transcriptase, i-TAF ivimbela i-HIV ekuphindaphindeni futhi inganciphisa inani le-HIV emzimbeni.I-Tenofovir alafenamide iyisidakamizwa, okusho ukuthi isidakamizwa esingasebenzi.Emzimbeni, i-tenofovir alafenamide iguqulelwa ku-Tenofovir diphosphate (TFV-DP).I-Tenofovir Alafenamide Fumarate yagunyazwa ngoNovemba 2015 yokwelashwa kwe-HIV-1.