I-Tranexamic Acid CAS 1197-18-8 Assay 99.0~101.0% (Titration)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Tranexamic Acid (CAS: 1197-18-8) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Tranexamic Acid,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Tranexamic Acid |
| Omqondofana | i-trans-4-(Aminomethyl) i-cyclohexanecarboxylic Acid;i-trans-Tranexamic Acid;I-TAMCHA;I-AMCHA;I-HAKU;I-AMCA;t-AMCHA;Trans-Amcha |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 1197-18-8 |
| I-Molecular Formula | I-C8H15NO2 |
| Isisindo samangqamuzana | 157.21 g/mol |
| I-Melting Point | >300℃(lit.) |
| Ukuzinza | I-Hygroscopic |
| Ukuncibilika kwamanzi | Incibilika Emanzini, Icishe Ikhanye |
| I-COA ne-MSDS | Iyatholakala |
| Isampula yamahhala | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | I-Crystalline Powder Emhlophe | Iyahambisana |
| Ukuncibilika | Incibilika Emanzini Ne-Glacial Acetic Acid, Icishe Ayincibiliki ku-Ethanol ne-Acetone (96%) | Iyahambisana |
| I-IR Spectrum | Ngokuvumelana ne-Tranexamic Acid CRS | Iyahambisana |
| pH | 7.0~8.0 | 7.32 |
| Ukulahlekelwa Ekumisweni | <0.50% | 0.06% |
| I-Sulfate Ash | <0.10% | 0.02% |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
| I-Chloride (Cl) | ≤140ppm | <140ppm |
| I-Arsenic (As) | ≤2ppm | <2ppm |
| Isivivinyo | 99.0~101.0% (nge-Titration) | 99.84% |
| Izinto Ezihlobene | ||
| Ukungcola A | <0.10% | 0% |
| Ukungcola B | <0.20% | 0.0815% |
| Ukungcola C | <0.10% | 0.0089% |
| Ukungcola D | <0.10% | 0.0063% |
| Ukungcola Okuphelele | <0.20% (Ngaphandle kwe-A,B) | 0.015% |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
I-Tranexamic Acid
I-C8H15NO2 157.2
i-trans-4-(Aminomethyl) i-cyclohexanecarboxylic acid;
Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans [1197-18-8].
INCAZELO
I-Tranexamic Acid iqukethe i-NLT 99.0% kanye ne-NMT 101.0% ye-C8H15NO2, ebalwa ngokomiswa.
UKUKHOMBA
• I-Infrared Absorption <197K>
ISIVIVINYO
• Inqubo
Isixazululo sesampula: 140 mg we-Tranexamic Acid ku-20 mL we-glacial acetic acid
Isistimu ye-Titrimetric
(Bheka i-Titrimetry <541>.)
Imodi: I-titration eqondile
I-Titrant: 0.1 N i-perchloric acid VS
Ukutholwa kwendawo yokugcina: I-Potentiometric
Ukuhlaziya
Isampula: Isixazululo sesampula
I-Titrate ngo-0.1 N perchloric acid VS, inquma indawo yokugcina nge-potentiometrically.Yenza ititration engenalutho.
I-mL ngayinye ka-0.1 N perchloric acid ilingana no-15.72 mg we-C8H15NO2.
Indlela yokwamukela: 99.0% -101.0% ngokomisiwe
UKUNGCOLA
Ukungcola Okungaphili
• Insalela Ekushiseni <281>: NMT 0.1%;1-g isampula isetshenziswa
• I-Heavy Metals, Indlela II <231>: NMT 10 ppm
• I-Chloride ne-Sulfate, i-Chloride <221>: Ingxenye engu-0.51-g ayibonisi i-chloride engaphezulu kokuhambisana no-0.1 mL ka-0.020 N hydrochloric acid (0.014%).
Ukungcola Okuphilayo
• Inqubo
Isigaba seselula: Chaza u-11.0 g we-anhydrous monobasic sodium phosphate ku-500 mL wamanzi, bese wengeza u-5 mL we-triethylamine, kulandele u-1.4 g we-sodium lauryl sulfate.Lungisa nge-phosphoric acid ehlanjululwe (10% w/w) iye ku-pH engu-2.5, bese uhlanza ngamanzi ukuya ku-600 mL.Hlanganisa lesi sixazululo no-400 ml we-methanol.
Isixazululo sokufaneleka kwesistimu: 0.2 mg/mL ye-USP Tranexamic Acid RS kanye no-0.002 mg/mL we-USP Tranexamic Acid Ehlobene Nenhlanganisela C RS emanzini
Isixazululo esijwayelekile: 50 µg/mL ye-USP Tranexamic Acid RS emanzini
Isixazululo sesampula: 10 mg/mL ye-Tranexamic Acid emanzini
Isistimu yeChromatographic
(Bona i-Chromatography <621>, Ukufaneleka Kwesistimu.)
Imodi: LC
Umtshina: UV 220 nm
Ikholomu: 4.6-mm × 25-cm;5-µm ukupakisha i-L1
Izinga lokugeleza: 1 mL/min
Usayizi womjovo: 20 µL
Isikhathi sokusebenza: izikhathi ezi-3 kunesikhathi sokugcinwa kwe-tranexamic acid
Ukufaneleka kwesistimu
Isampula: Isixazululo sokufaneleka kwesistimu
Izidingo zokufaneleka
Isixazululo: I-NLT 2.0 phakathi kwe-Tranexamic Acid kanye ne-0.002 mg/mL ye-tranexamic acid ehlobene nenhlanganisela C
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti lokungcola komuntu ngamunye engxenyeni ye-Tranexamic Acid ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × (0.1F)
i-rU = impendulo ephezulu yokungcola ngakunye okuvela kusixazululo Sesampuli
rS = impendulo ephezulu ye-tranexamic acid evela kusixazululo Esijwayelekile
CS = ukugcwala kwe-USP Tranexamic Acid RS kusixazululo Esijwayelekile (µg/mL)
I-CU = ukugcwala kwe-Tranexamic Acid kusixazululo Sesampula (mg/mL)
F = isici sokuphendula esihlobene (bona Ithebula Lokungcola 1)
Imibandela yokwamukela
Ukungcola komuntu ngamunye: Bheka Ithebula Lokungcola 1.
Ukungcola okuphelele: NMT 0.2%
[Qaphela-Ziba noma yikuphi ukuphakama okungaphansi kuka-0.025%.]
Ithebula Lokungcola 1
Yisho Isikhathi Esihlobene Sokugcina Isikhathi Sendlela Yokwamukela Isici Sempendulo Ehlobene, i-NMT (%)
Inhlanganisela ehlobene ne-Tranexamic acid Aa 2.1 1 0.1
Inhlanganisela ye-Tranexamic acid ehlobene ne-Bb 1.5 1.2 0.2
Inhlanganisela ehlobene ne-Tranexamic acid Cc 1.1 0.005 0.1
I-Tranexamic Acid 1.0 1.0 —
Inhlanganisela ehlobene ne-Tranexamic acid Dd 1.3 0.006 0.1
i-trans,trans-4,4¢-(Iminodimethylene)di(cyclohexanecarboxylic)asidi.
b cis-4-(Aminomethyl)cyclohexanecarboxylic acid.
c (RS) -4-(Aminomethyl) i-cyclohex-1-enecarbocylic acid.
d 4-Aminomethyl benzoic acid.
IZIVIVINYO EZITHILE
• Ukulahlekelwa Ekumisweni <731>: Yomisa ngo-1.00 g ku-105 ngaphansi kwe-vacuum amahora angu-2.Ilahlekelwa yi-NMT ngo-0.5% wesisindo sayo.
IZIDINGO EZENGEZIWE
• Ukupakisha Nokugcina: Londoloza ezitsheni eziqinile, futhi ugcine ezingeni lokushisa elingeqile ku-30.
• I-USP Reference Standards <11>
USP Tranexamic Acid RS Chofoza ukuze Ubuke Isakhiwo
I-USP Tranexamic Acid Ehlobene Nenhlanganisela C RS
(RS) -4-(Aminomethyl)cyclohex-1-enecarbocylic acid.
I-C8H13NO2 155
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
Izimpawu Zengozi Xi - Iyacasula
Amakhodi Engozi 36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
Incazelo Yokuphepha
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-S36 - Gqoka izingubo ezifanele zokuzivikela.
I-S37/39 - Gqoka amagilavu afanelekile kanye nokuvikela iso/ubuso
I-WGK Germany 2
I-RTECS GU8400000
I-HS Code 2922491100
I-Hazard Class IRRITANT
Ubuthi be-LD50 kumagundane, amagundane (mg/kg): 1500, 1200 iv (Melander)
I-Tranexamic Acid (CAS: 1197-18-8) iphuma kokwenziwa kwe-amino acid lysine.I-Tranexamic acid (ijwayele ukumakethwa ngendlela yethebhulethi njenge-Lysteda kanye ne-IV njenge-Cyklokapron e-US futhi njenge-Transamin, i-Transcam e-Asia, ne-Espercil eNingizimu Melika) kuvame ukunikezwa ukopha kakhulu.I-Tranexamic acid iyi-antifibrinolytic evimbela ngokuncintisana ukusebenza kwe-plasminogen ku-plasmin, i-molecule ebangela ukuwohloka kwe-fibrin.I-Fibrin iwuhlaka oluyisisekelo lokwakheka kwehlule legazi ku-hemostasis.I-Tranexamic acid inomsebenzi cishe ophindwe ka-8 kunomsebenzi we-antifibrinolytic we-analogue endala, i-ε-aminocaproic acid.Yaqala ukugunyazwa ngo-1957 futhi yathola imvume yayo yokuqala yase-US ngo-1986. I-Tranexamic Acid Applicaiton Isetshenziswa njengezimonyo ezimhlophe Isetshenziswa kabanzi emikhakheni yokuhlinzwa, imithi yangaphakathi, i-urology, obstetrics kanye ne-gynecology, njll. ukopha okungavamile ngesikhathi sokuhlinzwa, njll. Kubhekwa njengomuthi we-hemostatic, osetshenziselwa ikakhulukazi i-hemostasis ngemva kokuhlinzwa okukhulu kanye nangemuva kokubeletha.Yiqiniso, i-hemostasis cishe iyisizathu esincane sokuthi kungani imithi eminingi yokuxubha yengezwe ethembeni lokuba nomphumela.
I-Tranexamic Acid (CAS: 1197-18-8)
Ukuhlinzwa kwenhliziyo
Okuvame ukusetshenziswa ekuhlinzeni inhliziyo, kokubili ngaphandle nangaphandle kwe-cardiopulmonary bypass.Ithatha indawo ye-aprotinin.
Ukopha kokuya esikhathini
Isetshenziswa njengokwelashwa kokuqala okungewona amahomoni okopha kwesizalo esingasebenzi kahle, nokopha okukhulu okuhambisana ne-uterine fibroids.Ucwaningo lwakamuva lubonise iziguli ezelashwa nge-tranexamic acid zinamathuba amaningi okuba zithole i-thrombosis kanye necrosis kuma-fibroids azo, futhi zingase zibangele ubuhlungu nomkhuhlane.
Umphumela wokuba mhlophe
Izifundo zomtholampilo zeminyaka ziye zafakazela ukuthi i-tranexamic acid ingancibilikisa indawo ngempumelelo futhi ngokushesha, okusiza ukukhombisa isikhumba esimhlophe nesikhanyayo esiphelele.Umthelela osusa indawo we-tranexamic acid cishe izikhathi ezingama-50 ngaphezu kwe-Vitamin C, futhi izikhathi eziyishumi kune-AHA.Umkhawulo wokugxila wokusetshenziswa ngu-2% -3%, futhi ezimonyoni inani lilinganiselwa ku-0.5%
1. Ukuzinza okuhle
Uma kuqhathaniswa nezithako ezimhlophe zendabuko, i-tranexamic acid inokuqina okuphezulu, ukumelana ne-asidi ne-alkali, futhi ayithinteki kalula endaweni yokushisa;Akukho ukuvikelwa kwenkampani yenethiwekhi, akukho monakalo wesistimu yokudlulisela, akukho ukukhuthazwa.
2. Uhlelo lwesikhumba kulula ukulumunca
Ifaneleka ngokukhethekile izindawo ezikhanyisayo, ibe mhlophe kanye nokulinganisa ithoni yesikhumba sonke.Ngaphezu kokukhanyisa amabala, i-tranexamic acid ingaphinde ithuthukise ukucaca kombala wesikhumba uwonke kanye nokuba buthuntu kwesisindo sesikhumba sendawo.
3. Ingafiphala amabala amnyama, amafreckles aphuzi, izinduna, njll
Amabala amnyama abangelwa ukulimala kwe-UV nokuguga kwesikhumba nezinye izici.I-clotting acid ingavimbela umsebenzi we-tyrosinase nama-melanocyte, inciphise ukukhiqizwa kwe-melanin kusuka kungqimba oluyisisekelo lwe-epidermis, futhi iphinde ibe nomthelela wokukhipha amabala abomvu.
4. Ukuphepha okuphezulu
Ukugxila okuphezulu kakhulu kwezimonyo kungu-2% ~ 3%.
5. Umphumela wokuba mhlophe
I-Tranexamic Acid ifaneleka kuzo zonke izinhlobo zesikhumba ukuze kukhishwe umbala, isikhumba sibe mhlophe kanye nokunciphisa amabala, njengalezi: Ukuba nebala ngemva kokuchayeka elangeni;Amabala amnyama;Isikhumba esibucayi;Izinduna nokuvuvukala;Ukunakekelwa kwangemva kokuhlinzwa ngemuva kwe-laser, ukwelashwa kokukhanya kwe-pulsed.
