trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Purity >98.0% (HPLC) Afatinib Dimaleate Intermediate

Incazelo emfushane:

I-trans-4-Dimethylaminocrotonic Acid Hydrochloride

I-CAS: 848133-35-7

Ubumsulwa: >98.0% (HPLC)

Ukubukeka: Impushana Emhlophe Ukuya Kucishe Emhlophe

I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	I-trans-4-Dimethylaminocrotonic Acid Hydrochloride
Omqondofana	i-trans 4-Dimethylaminocrotonic Acid HCl;(E) -4-(Dimethylamino) -2-Butenoic Acid Hydrochloride;(E)-4-Dimethylaminocrotonic Acid Hydrochloride;(2E) -4-(Dimethylamino) kodwa-2-Enoic Acid Hydrochloride;I-Afatinib int-2
Inombolo ye-CAS	848133-35-7
Isimo Sesitoko	Esitokweni, Isikali Sokuhweba
I-Molecular Formula	I-C6H12ClNO2
Isisindo samangqamuzana	165.62
Ukuzwela	I-Hygroscopic.Kuyazwela Umswakama
I-Melting Point	160.0 ukuze 164.0 ℃
Ukuncibilika	I-DMSO (Kancane), i-Methanol (Kancane), Amanzi (Kancane)
I-COA ne-MSDS	Iyatholakala
Umsuka	Shanghai, China
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe Kuya Kucishe Emhlophe
Ukuhlanzeka / Indlela Yokuhlaziya	>98.0% (HPLC)
Ukuhlanzeka / Indlela Yokuhlaziya	>98.0% (NMR)
Umswakama (KF)	<0.50%
Izinsalela ekushiseni	<0.20%
Ukungcola Okukodwa	<0.50%
Izinsimbi Ezisindayo (njenge-Pb)	<20ppm
I-Infrared Spectrum	Ivumelana Nesakhiwo
1 H NMR Spectrum	I-Proton NMR Spectrum
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate ye-Afatinib, i-Afatinib Dimaleate

Iphakheji nesitoreji:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.

Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

I-Chromatographic Purity:

Ithuluzi: I-Agilent 1200 HPLC HPLC chromatograph, umtshina we-DAD.
Ikholomu: I-Agilent XDB-C18,250*4.6mm, 5μm
Isigaba seselula: B: 1.95g sodium octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml amanzi
C: i-acetonitrile
Ukulungiswa kwesigaba seselula esixubile: thatha isixazululo esingu-400ml B kanye ne-100ml acetonitrile, hlanganisa kahle futhi ngokulinganayo, bese umpompa uketshezi ngesigaba esisodwa.
Izinga lokugeleza: 0.5ml/min54bar
Izinga lokushisa lekholomu: 25℃
Ubude begagasi: 210nm
Isixazululo sesampula: isigaba seselula sisetshenziswe njenge-solvent, isampula eqinile: 0.0040g/2ml, usayizi wesampula 2.0μl.

Izinzuzo:

I-FAQ:

Isicelo:

I-trans-4-Dimethylaminocrotonic Acid Hydrochloride (i-CAS: 848133-35-7) i-reagent esetshenziselwa ukulungiswa kwe-tyrosine kinase inhibiting antitumor agents.I-trans-4-Dimethylaminocrotonic Acid Hydrochloride ingasetshenziswa njenge-intermediate ye-Afatinib (CAS: 439081-18-2), i-Afatinib Dimaleate (CAS: 850140-73-7), i-Neratinib (CAS: 698387-09-6).I-Afatinib isidakamizwa esigunyazwe ukwelashwa kwe-non-small cell lung carcinoma (NSCLC), esakhiwe ngu-Boehringer Ingelheim.Isebenza njenge-angiokinase inhibitor.NjengeLapatinib neNeratinib, i-Afatinib iyi-tyrosine kinase inhibitor (TKI) ephinde ivimbele ngendlela engenakulungiseka i-epidermal growth factor receptor 2 (Her2) kanye ne-epidermal growth factor receptor (EGFR) kinases.I-Afatinib ayisebenzi kuphela ngokumelene ne-EGFRizinguquko eziqondiswe isizukulwane sokuqala se-TKIs likeerlotinib noma i-gefitinib, kodwa futhi ngokumelene nalezo ezingazweli kulezi zindlela zokwelapha ezijwayelekile.Ngenxa yomsebenzi wayo owengeziwe ngokumelene ne-Her2, kuphenywa umdlavuza webele kanye neminye imidlavuza eqhutshwa yi-EGFR kanye ne-Her2.I-Neratinib eyakhiwe inkampani yase-US Wyeth iyi-epidermal growth factor receptor (EGFR) inhibitor engalungiseki.Iphuzu eliqondiwe kaningi le-molecule encane i-tyrosine kinase inhibitors eya ku-HER 2 ne-HER1 ngemva kwe-Lapatinib, futhi iyi-ErbB receptor tyrosine kinase inhibitor engabuyiseleki emuva.I-Neratinib ingavimbela ngokukhetha i-HER-1 kanye ne-HER-2 yomndeni we-EGFR(IC50 yayingu-92 nmol/L kanye no-59 nmol/L, ngokulandelanayo).Ucwaningo lwezokwelapha lubonise ukuthi i-Neratinib ibe nomthelela omkhulu wokwelapha kumdlavuza wamaphaphu ongewona omncane, umdlavuza wekoloni, kanye nomdlavuza webele.Uhlolo lwe-phaseⅡclinical lubonise ukuthi i-Neratinib ibonise ukusebenza kahle nokubekezelelana ezigulini ezine-HER-2 ezinomdlavuza webele othuthukisiwe ezake zathola ukwelashwa kwe-Trastuzumab noma cha.Isigaba Ⅲ sokuhlolwa komtholampilo womdlavuza webele saqedwa ngoSepthemba 2014.