I-Valsartan CAS 137862-53-4 Assay 98.0~102.0% API
I-Valsartan Yomkhiqizi kanye Nezixhumanisi Ezihlobene:
I-Valsartan CAS: 137862-53-4
I-L-Valine Methyl Ester Hydrochloride (H-Val-OMe·HCl) CAS: 6306-52-1
Igama Lekhemikhali | I-Valsartan |
Omqondofana | N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine |
Inombolo ye-CAS | 137862-53-4 |
Inombolo yeCAT | I-RF-API32 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C24H29N5O3 |
Isisindo samangqamuzana | 435.52 |
I-Melting Point | 116.0 ~ 117.0℃ |
Ukuzinza | I-Hygroscopic |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Emhlophe noma Engamhlophe;Ayinaphunga, iHygroscopic |
Ukuhlonza | I-spectrum ye-IR yesampula ifana ne-spectrum evamile yereferensi |
Ukuhlonza | Isikhathi sokugcinwa sesiqongo esikhulu ku-chromatogram yokulungiselelwa kokuhlolwa sihambisana naleso sokulungiselelwa okujwayelekile, njengoba kutholwe ku-Assay. |
Ukuncibilika | I-Soluble ku-Methanol ne-Ethanol, Incibilika Kancane ku-Ethylacetate, I-Soluble Kancane ku-Dichloromethane, Ayincibiliki Emanzini |
Umswakama (KF) | ≤1.00% |
I-Absorbance (420mm) | ≤0.02% (λ=420nm, C=0.05g/ml, L=1cm) |
Izinsalela ekushiseni | ≤0.10% |
Izinsimbi Ezisindayo | ≤10ppm |
I-D-Valsartan | ≤1.00% (HPLC) |
Izinto Ezihlobene (HPLC) | |
I-Butyryl-Valsartan | ≤0.20% |
I-Benzyl-Valsartan | ≤0.10% |
Ukungcola Okungaziwa Okukodwa | ≤0.10% |
Ukungcola Okuphelele | ≤0.30% (Ngaphandle kwe-D-Valsartan) |
I-Residual Solvents (GC) | |
I-Methanol | ≤3000ppm |
I-Ethyl Acetate | ≤5000ppm |
I-N, N-Dimethylformamide | ≤880ppm |
I-Toluene | ≤890ppm |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (i-HPLC ibalwa ngesisekelo se-anhydrous, i-solvent-free) |
Izinga Lokuhlola | I-United States Pharmacopoeia (USP) |
Ukusetshenziswa | I-Active Pharmaceutical Ingredient (API) |
I-Valsartan (CAS: 137862-53-4) Ukugeleza Kwenqubo Yokukhiqiza
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili kanye nomphakeli we-Valsartan (CAS: 137862-53-4) enekhwalithi ephezulu.I-Valsartan iyi-nonpeptide angiotensin II AT1 receptor antagonist, i-Antihypertensive, inamandla okucwaninga komfutho wegazi ophakeme kanye nokwehluleka kwenhliziyo.
Imiphumela ye-antihypertensive ye-Valsartan inamandla kunaleyo ye-enalapril futhi ilungele ukwelapha umfutho wegazi ophakeme, umfutho wegazi ophansi kuya omaphakathi, ikakhulukazi umfutho wegazi ophakeme wesibili obangelwa ukulimala kwezinso.Inganciphisa kakhulu i-proteinuria ezigulini ezinomfutho wegazi ophakeme ezinesifo sikashukela noma imisebenzi evamile yesibindi, futhi ingakhuthaza i-uric acid ne-sodium yomchamo ukuvikela izinso.I-Valsartan iphinde ilungele ukwehlisa izinga lokufa kwenhliziyo nemithambo yegazi ezigulini ezisengozini enkulu (ukwehluleka kwe-ventricular yesokunxele noma ukungasebenzi kahle) ngemuva kokuhlaselwa yinhliziyo.