I-Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Vitamin E-TPGS,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Vitamin E Polyethylene Glycol Succinate |
| Omqondofana | I-Vitamin E-TPGS;I-TPGS;Tocofersolan;i-α-Tocopherol Polyethylene Glycol Succinate;I-D-α-Tocopherol Polyethylene Glycol 1000 Succinate;I-alpha-Tocopherol Polyethylene Glycol Succinate |
| Isimo Sesitoko | Esitokweni, Isikali Sokuhweba |
| Inombolo ye-CAS | 9002-96-4 |
| I-Molecular Formula | C33H54O5.(C2H4O)n |
| I-Melting Point | 34.0 ~ 38.0℃ |
| Ukuminyana | 1.01g/cm3 |
| Kuyazwela | Izwela Umoya, Izwela Ukukhanya, Izwela Umswakama |
| I-WGK Germany | 2 |
| Isikhathi Sokugcina. | Indawo epholile neyomile (2~8℃) |
| I-COA ne-MSDS | Iyatholakala |
| Isampula | Iyatholakala |
| Chemical Family | I-Vitamin E ephumayo |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Okumhlophe Okumhlophe ukuya Kokuphuzi Okuphuzi Okuqinile | Iyahambisana |
| I-Identification (GC) | Isikhathi sokugcinwa kwesilinganiso esiphezulu sesixazululo sesampula sihambisana naleso sesixazululo Esijwayelekile | Iyahambisana |
| I-Melting Point | 34.0 ~ 38.0℃ | 36.0 ~ 36.6℃ |
| I-Assay D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| I-Tocopherol yamahhala | ≤1.5% | Iyahambisana |
| Ukuzungezisa okuqondile | ≥+24.0° | +24.5° |
| Ukuncibilika Emanzini | 20g Isampula Ingancibilika ku-80ml Amanzi Abilayo | Sula Ngaphakathi kwamahora angu-3 |
| I-Acid Value | ≤0.27ml (0.10 N I-Sodium Hydroxide) | 0.22ml |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
| I-Arsenic (As) | ≤1ppm | <1ppm |
| Ukuhola | ≤3ppm | <3ppm |
| I-Mercury (Hg) | ≤0.1ppm | <0.010ppm |
| Izincibilikisi Ezisele | ||
| I-Ethyl Acetate | ≤50ppm | Akutholwanga |
| I-Ethanol | ≤50ppm | 23 ppm |
| Inani Lepuleti Eliphelele | ≤1000CFU/g | <10CFU/g |
| Imvubelo kanye nesikhunta | ≤100CFU/g | <10CFU/g |
| I-Salmonella | Okubi | Okubi |
| Escherichia Coli | Okubi | Okubi |
| I-Psendomonas Aeruginosa | Okubi | Okubi |
| I-Staphylococcus Aureus | Okubi | Okubi |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina esitsheni esivalwe ngci.Gcina endaweni epholile, eyomile (2~8℃) futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
INCAZELO
I-Vitamin E I-Polyethylene Glycol Succinate iyinhlanganisela eyakhiwe yi-esterification ye-d-alpha tocopheryl acid succinate ne-polyethylene glycol.Ingxube ye-ester iqukethe ngokuyinhloko i-mono-esterified polyethylene glycol kanye nenani elincane le-di-esterified polyethylene glycol.Iqukethe i-NLT 25.0% ye-d-alpha tocopherol (C29H50O2).
UKUKHOMBA
• Ukuhlolwa Kokuhlonza I-Gas Chromatographic
Ukuhlaziya: Qhubeka njengoba kuqondiswe ekuhlolweni kokuqukethwe kwe-Alpha Tocopherol.
Imibandela yokwamukela: Isikhathi sokugcina sesiqongo esikhulu sesixazululo Sesampuli sihambisana naleso sesixazululo Esijwayelekile.
COMPOSITION
• Okuqukethwe kwe-Alpha Tocopherol
I-solvent: 0.25 mL ye-phenolphthalein TS ku-1 L yotshwala
Isixazululo sangaphakathi esijwayelekile: 12 mg/mL we-ethyl arachidate ku-isooctane
Isixazululo esijwayelekile: Dlulisa u-32.5 mg we-USP Alpha Tocopherol RS kuflask yokusabela efanelekile.Engeza u-2 mL we-pyridine no-0.5 mL we-N,O-bis(trimethylsilyl) trifluoroacetamide ne-1% trimethylchlorosilane, bese ushisisa i-flask ku-100 imizuzu eyi-10.Pholisa iflaski, engeza u-5.0 mL wesisombululo esijwayelekile sangaphakathi kulandele u-20 mL we-isooctane, bese unyakazisa.
Isixazululo esiyisampula: Dlulisa ubuningi obulingana no-0.100–0.160 g we-Vitamin E Polyethylene Glycol Succinate encibilikisiwe ngo-60 kushubhu yesiko (cishe amasentimitha angu-20 ubude no-2.5 cm ububanzi) efakwe isikulufu.Engeza u-40-50 mg we-ascorbic acid kanye nama-chips ambalwa abilayo, kulandele u-20 mL we-Solvent.[Qaphela—Reflux isixazululo ngobumnene ngaphandle kokuphuma kokuqukethwe.] Beka ishubhu endaweni yokushisa ebekwe ku-100–150.Lapho isampula selincibilike ngokuphelele, engeza u-0.25 g we-potassium hydroxide, bese uqhubeka nokushintshashintsha imizuzu engu-30.Susa ishubhu ekushiseni, futhi ngenkathi okuqukethwe kusashisa, engeza u-1-2 mL we-hydrochloric acid dropwise kuze kunyamalale umbala obomvana.[Isixwayiso—Ukusabela okushisayo.Vumela i-asidi ukuthi igeleze phansi ngaphakathi kweshubhu ukuvimbela ukuchaphazeka.] Pholisa ishubhu, bese ugeza izinhlangothi zeshubhu ngamanzi angama-20 ml.Engeza u-5.0 mL wesixazululo esijwayelekile sangaphakathi, ikepisi, bese unyakazisa ukuze uqinisekise ukuxutshwa okuphelele.Vumela ithubhu ukuthi ime kuze kube yilapho kwakhiwa izingqimba ezimbili ezihlukene.Dlulisa u-2.5–3.5 mL wongqimba olungaphezulu kuflask yokusabela efanelekile, bese wengeza u-2.0 mL we-pyridine kulandele u-2.5 mL we-N,O-bis(trimethylsilyl) trifluoroacetamide ne-1% trimethylchlorosilane.Shisisa i-flask ku-100 imizuzu engu-10.Phola, bese wengeza u-12 mL we-isooctane.
Isistimu yeChromatographic
(Bona i-Chromatography 621, Ukufaneleka Kwesistimu.)
Imodi: GC
Umtshina: I-ionization yomlilo
Ikholomu: 0.25-mm × 15-m fused-silica capillary;ehlanganiswe nefilimu engu-0.25-µm yesigaba G27
Izinga lokushisa
Umjovo: 280
Umtshina: 345
Ikholomu: Bheka Ithebula 1.
Ithebula 1
Ithempelesha Yokuqala(°) Irempu Yezinga lokushisa (°/min) Ithempelesha Yokugcina (°) Ukubamba Isikhathi Emazingeni Okushisa Okugcina (min)
260 20 340 1
Igesi yenkampani: i-Helium
Izinga lokugeleza: 1.5 mL/min
Usayizi womjovo: 1 µL
Uhlobo lomjovo: Isilinganiso sokuhlukaniswa, 200:1
Ukufaneleka kwesistimu
Isampula: Isixazululo esijwayelekile
Izidingo zokufaneleka
Isici somsila: I-NMT 2.0 yenani eliphakeme le-alpha tocopherol
Ukuchezuka okujwayelekile okuhlobene: I-NMT 2.0% yesilinganiso sendawo ephakemeyo ye-alpha tocopherol endaweni ephakemeyo evamile yangaphakathi
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti le-d-alpha tocopherol (C29H50O2) engxenyeni ye-Vitamin E Polyethylene Glycol Succinate ethathiwe:
Umphumela = (RU/RS) × (WS/WU) × 100
RU= isilinganiso sangaphakathi esijwayelekile (indawo ephakemeyo ye-alpha tocopherol/indawo ephakeme yezinga langaphakathi) kusukela kusixazululo Sesampuli
RS= isilinganiso sangaphakathi esijwayelekile (indawo ephakemeyo ye-alpha tocopherol/indawo ephakeme yezinga langaphakathi) kusukela kusixazululo Esijwayelekile
I-WS= isisindo se-USP Alpha Tocopherol RS esisetshenziselwa ukulungisa isisombululo Esijwayelekile (mg)
I-WU= isisindo se-Vitamin E Polyethylene Glycol Succinate esithathiwe ukulungisa Isampula yesixazululo (mg)
Indlela yokwamukela: NLT 25.0%
IZIVIVINYO EZITHILE
• I-Optical Rotation, Specific Rotation 781S
[Qaphela-Lokhu kuhlolwa kukhomba i-d-alpha tocopherol ngemva kwe-saponification.]
Isixazululo esiyisampula: Dlulisa u-0.9 g we-Vitamin E Polyethylene Glycol Succinate, encibilikisiwe ku-60, eshubhu lokuhlola elifanele elifakwe ikepisi, bese uncibilika ku-10.0 mL wotshwala.Beka ishubhu endaweni yokushisa ebekwe ku-100-105.[Qaphela-Reflux ikhambi ngobumnene ngaphandle kokuphuma kokuqukethwe.] Uma isampula selincibilike ngokugcwele, engeza ama-pellets angu-2–3 e-sodium hydroxide, bese uqhubeka nokushintshashintsha ngemva kwemizuzu engu-30 eyengeziwe.Susa ishubhu ekushiseni, futhi ngenkathi okuqukethwe kusashisa, nciphisa ukusebenzisa i-phenolphthalein njengenkomba ngokungeza kancane kancane u-10 mL wengxube yamanzi ne-hydrochloric acid (1:1) kuze kunyamalale umbala obomvana.[Isexwayiso-Ukusabela kwe-Exothermic.Vumela ikhambi le-asidi liconse ngaphakathi kweshubhu ukuze kuvinjelwe ukuchaphazeka.] Pholisa ishubhu, ikepisi, futhi unyakazise kuze kuhlanganiswe kahle okuqukethwe.Engeza u-25.0 mL we-heptane, i-cap, bese unyakazisa iminithi elingu-1 ukuqinisekisa ukuxutshwa ngokuphelele.Vumela ithubhu ukuthi ime kuze kube yilapho kwakhiwa izingqimba ezimbili ezihlukene.Dlulisela ungqimba olungaphezulu kushubhu yesiko elihlanzekile, elomile, bese wengeza u-10.0 mL wamanzi esixazululweni esitholiwe.Cap, nyakazisa, bese uvumela izendlalelo ukuthi zihlukane.Dlulisa ungqimba olungaphezulu kushubhu ehlanzekile, eyomile.Engeza u-10.0 mL wesixazululo se-potassium ferricyanide, esilungiswe ngokuncibilikisa u-2 g we-potassium ferricyanide ku-10.0 mL we-0.2 M sodium hydroxide, bese ubuyisela ikepisi.Shake ngamandla amasekhondi angu-45, bese uvumela izendlalelo ukuthi zihlukanise imizuzu engu-30.Uma ungqimba lwe-heptane olungaphezulu lucacile, qhubeka nesilinganiso sokujikeleza okuthile;uma kungacacile, yomisa phezu kwe-anhydrous sodium sulfate ngaphambi kokuqhubeka nokuhlola.[Qaphela-Sebenzisa imiphumela yokuhlolwa Kokuqukethwe kwe-Alpha Tocopherol ukuze ubale ukuzungezisa okuthile.]
Indlela yokwamukela: NLT +24.0
• Ukuncibilika Emanzini
Isampula: 20 g we-Vitamin E ecibilikile ye-Polyethylene Glycol Succinate
Ukuhlaziya: Faka Isampula esitsheni sengilazi ku-stirrer kazibuthe.Ngokushesha faka u-80 ml wamanzi abilayo ngenkathi uvuselela.Vumela ukupholisa ekamelweni lokushisa ngokuvuselela njalo.
Indlela yokwamukela: Isixazululo siba sobala phakathi namahora ama-3.
• Inani le-Acid
Isampula: 1 g ye-Vitamin E Polyethylene Glycol Succinate
Ukuhlaziya: Chaza Isampula ku-25 mL wengxube yotshwala ne-ether (1:1) esuswe yaba yi-phenolphthalein nge-0.1 N sodium hydroxide.Engeza u-0.5 mL we-phenolphthalein TS, bese u-titrate ngo-0.10 N sodium hydroxide kuze kube isixazululo sihlala sibomvana ngokuphazima kweso ngemva kokuzamazama imizuzwana engu-30.
Indlela yokwamukela: I-NMT 0.027 mEq/g, okulingana ne-NMT 0.27 mL ka-0.10 N sodium hydroxide
IZIDINGO EZENGEZIWE
• Ukupakisha Nokugcina: Londoloza ezitsheni eziqinile, futhi ugcine uvikelekile ekukhanyeni.
• Ukulebula: Ukulebula kubonisa okuqukethwe kwe-d-alpha tocopherol, evezwe ngo-mg/g.
• I-USP Reference Standards 11
USP Alpha Tocopherol RS
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-Vitamin E I-Polyethylene Glycol Succinate (I-Vitamin E-TPGS; i-TPGS; i-Tocofersolan) (i-CAS: i-9002-96-4) iwumkhiqizo wokwenziwa.Itholakala njengengcina emhlophe ephuzi ukuya kophuzi ngokuphaphathekile Iqinile futhi ayinambitheki nhlobo.Ngokomakhemikhali, ingxube ehlanganiswe ngokuyinhloko i-monoesterified polyethylene glycol 1000, i-diesterified polyethylene glycol 1000, i-polyethylene glycol 1000 yamahhala, ne-tocopherol yamahhala.
I-Vitamin E Polyethylene Glycol Succinate isetshenziswe kabanzi ocwaningweni lwezemithi, njenge-solubilizer, umgqugquzeli wokumuncwa, i-emulsifier, i-plasticizer kanye nomthwali wohlelo lokulethwa kwezidakamizwa olungancibiliki emanzini noma olunamafutha, njengokuhlakazeka okuqinile, umthwali wokulethwa kwezidakamizwa zamehlo, umthwali we-intranasal. ukulethwa kwezidakamizwa, njll. Njengezithasiselo zokudla.
I-Vitamin E I-Polyethylene Glycol Succinate iphuma ku-vitamin E encibilika emanzini, yakhiwa ngokusabela iqembu le-carboxyl likavithamini E succinate neqembu le-hydroxyl le-polyethylene glycol.Ngenxa yokuthi iqukethe kokubili i-vitamin E lipophilic group kanye ne-polyethylene glycol hydrophilic long chain, inezici ezinhle ze-surfactant kanye nokuncibilika kwamanzi, okungakhuphula kakhulu ukumuncwa kwezidakamizwa ezingancibiliki emgudwini wamathumbu, ukwanda kwe-bioavailability.
Eminyakeni yamuva nje, izifundo eziningi zithole ukuthi i-TPGS ayisebenzisi nje kuphela njengezihlanganisi zemithi, kodwa futhi inezici eziningi eziyingqayizivele, njengezithuthukisi zokumuncwa kanye nama-ejenti okuguqula ukuphikiswa kwezidakamizwa eziningi, i-TPGS ingasetshenziswa futhi kuma-prodrugs, ama-micelles, ama-liposomes, i-TPGS-copolymer. abathwali ukuze kuthuthukiswe ukunyibilika, ukungena kanye nokuzinza kokulungiswa, ukuze kuzuzwe ukukhululwa okuhamba kancane, okulawulwayo kanye nomphumela wokukhomba, ukukhuthaza ukumuncwa kwezidakamizwa.
1. Ezemithi - I-Vitamin E-TPGS ithuthukisa kakhulu ukumuncwa, ukutholakala kwe-bioavailability kanye nempumelelo yezithako zemithi (ama-API)
2. Izithako zokudla - I-Vitamin E-TPGS isetshenziselwa ukwenza izithasiselo, ikakhulukazi lezo ezidalwe ukuthuthukisa ukumuncwa kwe-vitamin E nezinye imisoco ye-lipophilic kanye ne-nutraceuticals.
3. Ukudla Nesiphuzo - I-Vitamin E-TPGS ingasetshenziswa ukuqinisa ukudla neziphuzo, iziphuzo zezemidlalo, amanzi namajusi
4. Ukunakekelwa Komuntu Siqu - I-Vitamin E-TPGS isebenza njenge-ethanol mahhala, i-hypoallergenic, i-emulsifier/i-excipient engacasuli ekunakekelweni komuntu siqu nasezinhlelweni zezimonyo.
5. Imikhiqizo Yokondliwa Kwezilwane - I-Vitamin E-TPGS inikeza i-vitamin E emuncwa kakhulu futhi etholakala nge-bioavailable ezilwaneni ezingamunyi kahle izinhlobo zendabuko zikavithamini E.
I-Vitamin E i-polyethylene glycol succinate iphuma ku-vitamin E (tocopherol) ene-esterified esetshenziswa ngokuyinhloko njenge-solubilizer noma i-emulsifying agent ngenxa yezakhiwo zayo ezitholakalayo.Ngokwesakhiwo, i-amphipathic kanye ne-hydrophilic, ngokungafani ne-tocopherols, ngakho-ke i-derivative encibilikayo emanzini engasetshenziswa ekwakhiweni kwemithi njengama-capsules, amaphilisi, i-hot-melt extrusion, ama-microemulsions, imikhiqizo ye-topical, nama-parenterals.Enye yezinhlelo ezibaluleke kakhulu ukusetshenziswa kwayo njengemoto yokwakhiwa kokulethwa kwezidakamizwa okususelwa ku-lipid.Ingasetshenziswa futhi njengomthombo kavithamini E. I-Vitamin E i-polyethylene glycol succinate ibonakaliswe ngokuphathelene nendlela yayo yokusebenza futhi yafundwa njenge-Pglycoprotein inhibitor.
I-Vitamin E i-polyethylene glycol succinate ayihambelani nama-acids aqinile nama-alkali aqinile.
GRAS esohlwini.Kufakwe ku-FDA Inactive Ingredients Database (isixazululo se-ophthalmic noma amaconsi; amaphilisi omlomo, isixazululo, ithebhulethi; isixazululo sesihloko noma amaconsi).Kufakwe ohlwini lwe-Canada Lwezithako Ezingezona ezemithi Ezamukelekayo.
