I-Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2 API Ikhwalithi ephezulu
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I-Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Igama Lekhemikhali | I-Vonoprazan Fumarate |
| Omqondofana | I-TAK-438 |
| Inombolo ye-CAS | 1260141-27-2;881681-01-2 |
| Inombolo yeCAT | I-RF-API99 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
| I-Molecular Formula | I-C21H20FN3O6S |
| Isisindo samangqamuzana | 461.463 |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystalline Powder Emhlophe noma Ecishe Emhlophe |
| Ukuhlonza 1 H-NMR | Ngokuvumelana nezinga |
| Ukuhlonza IR | I-IR Absorption spectrum yesampula yekhonkodanti enezinga eliyinkomba |
| Ukuhlonza HPLC | Isikhathi sokugcinwa kwesampula evumelana nezinga lokubhekisela |
| Okuqukethwe Amanzi | ≤0.50% |
| Izinsalela ekushiseni | ≤0.20% |
| Izinsimbi Ezisindayo (njenge-Pb) | ≤20ppm |
| Izinto Ezihlobene | |
| Ukungcola A | ≤0.20% |
| Ukungcola B | ≤0.15% |
| Ukungcola C | ≤0.15% |
| Noma Ikuphi Okunye Ukungcola | ≤0.10% |
| Ukungcola Okuphelele | ≤1.0% |
| Izincibilikisi Ezisele | |
| I-Methanol | ≤0.30% |
| I-Ethanol | ≤0.50% |
| I-Ethyl Acetate | ≤0.50% |
| Indlela Yokuhlola / Yokuhlaziya | 98.0%~102.0% (Nge-HPLC) |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-API |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama.
I-Vonoprazan Fumurate (TAK-438) (i-CAS: 1260141-27-2; 881681-01-2), i-proton pump inhibitor (PPI), iyisivimbeli esinamandla futhi esisebenzayo ngomlomo se-potassium-competitive acid (P-CAB), ene-antisecretory umsebenzi.I-Vonoprazan Fumarate ivimbela umsebenzi we-H+,K+-ATPase ku-porcine gastric microsomes nge-IC50 ye-19 nM ku-pH 6.5.I-Vonoprazan Fumarate (Takecab), etholwe futhi yathuthukiswa ngu-Takeda no-Otsuka, yavunywa yi-PMDA yaseJapane ngoDisemba 2014. I-Vonoprazan Fumarate isetshenziselwa ikakhulukazi ukwelapha ukutheleleka kwe-helicobacter pylori, i-reflux ye-gastroesophageal, isilonda se-peptic, isilonda se-duodenal, esophagitis, i-gas. isilonda nezinye izifo ezihlobene ne-gastric acid.Umkhiqizo unokuvimbela okuqinile, okuhlala njalo kwe-gastric acid secretion.Ngomthamo wokwelashwa, i-Vonoprazan Fumarate inomphumela omncane kwamanye ama-enzyme futhi inomthelela omncane emisebenzini yomzimba yomzimba.Kuphephile futhi kuyabekezeleleka.
